Scientists from the University of Rochester has identified a location in the genome of influenza virus "switch", which blocks the replication of the virus. Finding the path switch control, they will be able to stop the spread of flu.
Under the guidance of Professor of chemistry Douglas Turner scientists have identified RNA, which triggers the production of two proteins required for virus spread. The production of the second protein RNA involves the process of splicing, when two remote fragment of the long molecules are joined together, and the intermediate segment is discarded.
Scientists believe that one of the objects of splicing can be a potential switch RNA. Stopping the connection of fragments of the molecule, you can block infection. Scientists analyzed data from the sequencing of the genome of influenza and built a 2-D model of RNA molecules.
Scientists have discovered two ways of preventing splicing strands of RNA. The first option assumes that the fragments of the molecule for splicing will be hidden from each other using pseudouser. The second option involves the insertion of additional molecules, which will make the splicing impossible. In any case, the spread of the virus will be stopped.
Scientists believe that the discovery will lead to new antiviral drugs for the treatment of severe influenza infections.
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