Maternal care in some way serves the reprogramming of the immune system of the brain in such a way that in the future an active immune genes do not give the pleasure center in the brain to remember about drugs.
The cause of dependence on opiate consider their impact on the pleasure center in the brain, but the effect is partly mediated. Opiates stimulate glial cells, the utility of the cells of the nervous system that performs including immune function, and glial cells send a signal to the adjacent nucleus of the brain. Drug substance simulate the inflammation that causes the cells to glial cell has again and again to stimulate the pleasure center.
Experiments on rats have shown that addiction to drugs does not occur if in childhood animal received an increased dose of maternal affection. Researchers from Duke University (USA) pulled out the little rat out of the cage with his mother and after 15 minutes had to be returned back. This manipulation was motivated by his mother to intensive care and the care of new-found pups: she brought order to their hair, licking, etc. In the control group calves remained with their mothers all the time, although due to the individual characteristics they have in varying degrees been covered maternal care. Then a young rats was offered morphine, and to monitor the emergence of craving for the drug, they were placed in a double-chamber cage: on one half of the animals received the drug, while the other had only saline solution.
As expected, rats quickly understood what was happening, and tried to stay on the half, which gave the morphine. Within a month three times a week animals for five minutes was placed in a two-chamber cell, and without receiving morphine, rats still wanted to go on a "drug" half. This, however, was only normal rats. Those animals that received in childhood more intensive maternal care showed rapid attenuation dependence; in the end they ceased to prefer one half cell to the other. But sooner or later dependence on the drug faded at all.
Eight weeks after the first dose of morphine animals were again given a portion of the drug, but very little, only to stimulate the fading correlation. Normal rats quickly recalled his passion and at the earliest opportunity ran on morphine half cells. On the contrary, those that have been especially treated kindly in childhood, remained indifferent.
According to the authors, the trick lies in the immune protein-interleukin-10 (IL-10). It inhibits the signal, which glial cells stimulate the pleasure center. The more IL-10 in the brain, the less likely it is that morphine conquer the pleasure center, and the easier it is for the body to fight the temptation.
We kindly treated rats, the levels of Il-10 was increased, and the increased activity interlacing gene is associated with its epigenetic regulation. His DNA altered pattern of methylation, and gene anti-inflammatory IL-10 becomes stable active throughout life. But how maternal touch preprogramming Department of the immune system in the brain remains to be seen. Research results are being prepared for publication in the Journal of Neuroscience.
Scientists have confirmed their results by entering the rats a drug that stimulates the production of interleukin-10. It is possible to reduce the power of drug addiction in animals without excessive parental care. The researchers emphasize that the effect of morphine maternal affection had no effect, that is, the body gets from the drug the same pleasure, just in the future, so to speak, recalls this experience with no regrets.
In the next step, the researchers want to test the effect on the development of drug dependence lack of maternal attention. In other words, can we assume that orphans grow up to be the most accurate clients drug dealers.
Prepared according to Medical Xpress.
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to be continued
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